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Because no human safety trial for IGF-1 LR3 exists, risk assessment must be extrapolated from the pharmacology of native IGF-1 and from the mechanism of IGF1R activation
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5.3.3 Synbiotics Synbiotics, a mixture containing live microorganisms and substrate(s) selectively utilized by host microorganisms that confer health benefits on the host (Swanson et al., 2020), have been employed to improve the diversity and richness of a dysbiotic gut, favor saccharolytic metabolism, reduce serum levels of free IS, improve intestinal permeability and alleviate constipation (Celano et al., 2023